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KMID : 0665220140270050837
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Korean Journal of Food and Nutrition
2014 Volume.27 No. 5 p.837 ~ p.844
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Screening of Biological Activities of Ethanol Extracts from Fermented Gastrodia elata Blume
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Kim Mi-Hyun
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Abstract
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This study was carried out to analyze the differences in p-hydroxylbenzyl alcohol (HBA) content, antitumor and anti-obesity activities and tyrosinase inhibitory activity between non-fermented G. elata (NFGP) and fermented G. elata powder. The HBA content, which is an index-component of G. elata decreased from 1.58 mg/g before fermentation to 1.07, 0.32, and 0.13 mg/g after the 1st fermentation (1st FGP), 2nd fermentation (2nd FGP) and 3rd fermentation (3rd FGP), respectively. The anti-proliferation effects on the cell lines HT29 and AGS were significantly higher for the fermented G. elata than the NFGP. The antitumor activity was also increased in a fermentation number-dependent manner. During adipocyte differentiation, the ethanol extract of the 3rd FGP inhibited lipid accumulation in 3T3-L1 cells significantly better than NFGP and the 1st FGP, treated at the concentration of 10μg/mL. The tyrosinase inhibitory activity of the 2nd FGP at 600μg/mL over was higher than that of kojic acid. At the concentration of 1,000μg/mL, the tyrosinase inhibitory activity was increased in a fermentation number-dependent manner. From these results, the fermented G. elata, especially the 3rd FGP, is expected to be good candidate for the development of functional food and agents with antitumor, anti-obesity, and tyrosinase inhibitory potential.
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KEYWORD
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antitumor activity, anti-obesity activity, tyrosinase inhibition, Gastrodia elata Blume, fermentation
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